Who? Who Am I? is the biggest question that a Vedantin asks himself. Till he finds the answer to that question, he keeps searching through various studies, meditation and reflection. The first stage in this quest is to understand that the subject I is different from the objects mind, body and intellect and finding out the reality of the subject and the impermanent nature of the objects.
What? What life has to offer will always be a mystery and to treat the future with a positive attitude without being afraid.
Where? Where life takes you to go cheerfully and with excitement will make you a wonderful person, ie, a person full of wonder.
Why? Why things happen should always be allowed to be a mysterious and accepted as the reason for our being here.
When? When life deals you with eggs, making omelettes will make you strong enough to handle all the other Ws in this list.